2025 Lexus Rx 350 Hybrid Mpg. Based on 2024 estimates, the rx hybrid leads the luxury midsize suv segment with 36 mpg combined (37 mpg in the city, 34 mpg on the highway). The motortrend buyer's guide has the 2025 lexus rx hybrid specs you need, from dimensions and cargo space to power and mpgs.

Edmunds also has lexus rx pricing, mpg, specs, pictures, safety features, consumer reviews and more. The epa’s data shows that the most efficient rx model is the rx350h, which carries claimed ratings of 37 mpg city and 34 mpg highway.